血红蛋白A2现象发生机制的研究——“红细胞HbA2”为HbA2与HbA的结合产物

为了弄清血红蛋白A₂现象的发生机制,我们对“红细胞HbA₂”的化学组成进行了分析。“红细胞HbA₂”的双向电泳结果表明,它含有两种血红蛋白成分:一种相当于HbA,另一种很可能是溶血液HbA₂。其单向二次电泳结果也证明,它是由溶血液HbA₂和HbA所组成。结果初步说明,盘红细胞中HbA₂可能与HbA结合存在。两者可能有相互作用,也许这是产生血红蛋白A₂现象的原因。

MECHANISM OF HEMOGLOBIN A2 PHENOMENON "ERYTHROCYTE HbA2" IS A BINDING PRODUCT OF HbA2 AND HbA

1. Chemical composition of erythrocyte HbA₂ was analyzed in order to clarify the mechanism of hemoglobin A₂ phenomenon. The paper reports the hemoglobin composition of erythrocyte HbA₂.2. The results of two-dimensional electrophoresis showed that erythrocyte HbA₂ contains two Hb components: one corresponds to HbA and the other most probably is hemolysate HbA₂.3. The results of one-dimensional re-electrophoresis showed definitly that erythrocyte HbA₂ is composed of hemolysate HbA₂ and HbA.4. Tentative conclusion: HbA₂ may be combined with HbA in erythrocyte, i.e. there is probably interaction between the two hemoglobins. This is perhaps the possible cause of hemoglobin A₂ phenomenon.