Assignment of the gene locus for the sixth component (C6) of complement in mice to chromosome 15 |
| |
Authors: | Jun-ichiro Hayakawa Hiroko Nikaido Tsutomu Koizumi |
| |
Affiliation: | (1) Institute for Experimental Animals, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920, Japan |
| |
Abstract: | A structural locus (C-6) for the sixth component of complement in mice is assigned to chromosome 15. Three-point linkage analysis indicated that the order of loci is C-6, Gpt-1, Gdc-1, and that the map distances are 25.9±4.9 between C-6 and Gpt-1, and 36.4±5.5 between C-6 and Gdc-1. Since Gdc-1 is more distal than Gpt-1, and C-6 is 26 cM away from Gpt-1, it is estimated that the C-6 is proximal to the centromere. In addition, a new C6 form found in AKR mice is described. We propose the designation C6B for it and C-6b for the allele encoding C6B.Abbreviations used in this paper IEF isoelectric focusing - GPT glutamic-pyruvic transaminase - GDC L-glycerol 3-phosphate dehydrogenase - cM centimorgan |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|