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The isoprostanes: Novel prostaglandin-like products of the free radical-catalyzed peroxidation of arachidonic acid |
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| Authors: | Tsan Liu Arnold Stern L. Jackson Roberts Jason D. Morrow MD |
| Affiliation: | (1) Department of Medical Research, Yuan's General Hospital, Kaohsiung, Taiwan;(2) Department of Pharmacology, New York University of Medicine, New York, N.Y.;(3) Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn., USA;(4) 526 MRB-I, Vanderbilt University, 23rd and Pierce Avenues, 37232-6602 Nashville, TN, USA |
| Abstract: | The isoprostanes (IsoPs) are a unique series of prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of arachidonic acid. This review summarizes our current knowledge regarding these compounds. Novel aspects of the biochemistry and bioactivity of IsoPs are detailed and methods by which these compounds are analyzed are discussed. A considerable portion of this review deals with the utility of measuring IsoPs as markers of oxidant injury in human diseases particularly in association with risk factors that predispose to atherosclerosis, a condition in which excessive oxidative stress has been causally implicated. |
| Keywords: | Isoprostane Lipid Peroxidation Eicosanoid Free radical |
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