Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions |
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| Authors: | Sandra Feijóo-Bandín María García-Vence Vanessa García-Rúa Esther Roselló-Lletí Manuel Portolés Miguel Rivera |
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| Affiliation: | 1. Cellular and Molecular Cardiology Research Unit and Department of Cardiology, Institute of Biomedical Research and University Clinical Hospital, Santiago de Compostela, Spain;2. Cardiocirculatory Unit, Health Institute of La Fe University Hospital, Valencia, Spain |
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| Abstract: | Two-pore channels (TPC1-3) comprise a subfamily of the eukaryotic voltage-gated ion channels (VGICs) superfamily that are mainly expressed in acidic stores in plants and animals. TPCS are widespread across the animal kingdom, with primates, mice and rats lacking TPC3, and mainly act as Ca+ and Na+ channels, although it was also suggested that they could be permeable to other ions. Nowadays, TPCs have been related to the development of different diseases, including Parkinson´s disease, obesity or myocardial ischemia. Due to this, their study has raised the interest of the scientific community to try to understand their mechanism of action in order to be able to develop an efficient drug that could regulate TPCs activity. In this review, we will provide an updated view regarding TPCs structure, function and activation, as well as their role in different pathophysiological processes. |
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| Keywords: | endolysosome NAADP PI(3,5)P2 TPC1 TPC2 |
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