FHA domain pThr binding specificity: it's all about me |
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| Authors: | Coquelle Nicolas Glover J N Mark |
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| Affiliation: | Department of Biochemistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, AB T6G2H7, Canada. |
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| Abstract: | The FHA domain is a phospho-peptide binding module involved in a wide range of cellular pathways, with a striking specificity for phospho-threonine over phospho-serine binding partners. Biochemical, structural, and dynamic simulations analysis allowed Pennell and colleagues to unravel the molecular basis of FHA domain phospho-threonine specificity. |
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