Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily |
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| Authors: | William S. Modi Michael Dean Hector N. Seuanez Naofumi Mukaida Kouji Matsushima Stephen J. O'Brien |
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| Affiliation: | (1) Biological Carcinogenesis and Development Program, Program Resources, Inc., National Cancer Institute, Frederick Cancer Research Facility, 21701 Frederick, MD, USA;(2) Laboratory of Viral Carcinogenesis, National Cancer Institute, 21701 Frederick, MD, USA;(3) Laboratory of Molecular Immunoregulation, National Cancer Institute, 21701 Frederick, MD, USA |
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| Abstract: | Summary Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8, suggested gene symbol IL8) is a cytokine that chemoattracts and activates neutrophils. Using a panel of human-rodent cell hybrids that preferentially segregate human chromosomes and in situ hybridization, the MDNCF/IL-8 gene was placed on the human gene map at position 4q12-q21. This is the same location where at least three other members (platelet factor 4, melanoma growth stimulatory activity, and interferon- induced factor) of the platelet factor 4 gene superfamily reside. In addition, a restriction fragment length polymorphism was identified using MDNCF as a probe in screening genomic DNA digested with HindIII from unrelated individuals.On leave from Genetics Section, Instituto Nacional do Cancer (RJ)/ Department of Genetics, Universidade Federal do Rio de Janeiro, Brazil |
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