Purification and some properties of Clostridium botulinum type AB toxin |
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| Authors: | Genji Sakaguchi Sumiko Sakaguchi Shunji Kozaki Motohide Takahashi |
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| Institution: | University of Osaka Prefecture, College of Agriculture, Sakai - shi, Osaka 591, Japan;Chiba Serum Institute, Ichikawa - shi, Chiba 272, Japan |
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| Abstract: | Abstract The progenitor toxin of Clostridium botulinum type AB was purified; both large-sized (L) and medium-sized (M) toxins were found. The toxicity of M toxin increased by about 10-fold upon trypsinization; the increase was due mostly to type B toxin and a little to type A toxin. M toxin appeared to consist of one molecule each of toxic and nontoxic components. The activated toxic component was made up of four fragments, A-H- and L-chains and B-H- and L-chains. AB toxin may be a mixture of A and B toxins. |
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| Keywords: | Botulinum AB toxin AB progenitor toxin fragments of AB toxin molecular structure of AB toxin |
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