| 活性氧自由基诱发的胆红素聚合、聚集及稳定自由基的形成 |
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| 引用本文： | 刘湘陶,孙福祿,赵立文,王夔,杨正红,周以华.活性氧自由基诱发的胆红素聚合、聚集及稳定自由基的形成[J].中国生物化学与分子生物学报,1990,6(5):437-443. |
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| 作者姓名： | 刘湘陶 孙福祿 赵立文 王夔 杨正红 周以华 |
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| 作者单位： | 北京医科大学药学院，北京医科大学天然药物及仿生药物实验室，北京医科大学天然药物及仿生药物实验室，中国计量科学研究院标准物质研究中心 北京 |
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| 基金项目： | 中国科学院自然科学基金 |
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| 摘 要： | 为了深入了解胆红色素类结石形成的触发机制,我们研究了活性氧自由基与胆红素的作用。结果表明:·O_2和·OH均可诱发胆红素聚合和聚集,井使胆红素转变成稳定的自由基,从而引起脂质过氧化和透明质酸分子降解。经自由基处理的胆红素溶解度减小,粒度分布趋向颗粒变大.根据以上事实,重点讨论了自由基触发的胆色素类结石的致病过程。
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| 关 键 词： | 胆红素 胆色素类结石 自由基 |
| 收稿时间： | 1990-10-20 |
Polymerization, Aggregation and Stable Free Radical Formation of Bilirubin Induced by Active-oxygen Free Radicals |
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| Liu,Xiang-tao Sun,Fu-lu Zhao,Li-wen wang,Kui Yang,Zhen-hong Zhou,Yi-hua.Polymerization, Aggregation and Stable Free Radical Formation of Bilirubin Induced by Active-oxygen Free Radicals[J].Chinese Journal of Biochemistry and Molecular Biology,1990,6(5):437-443. |
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| Authors: | Liu Xiang-tao Sun Fu-lu Zhao Li-wen wang Kui Yang Zhen-hong Zhou Yi-hua |
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| Institution: | (School of Pharmaceutical Sciences, Beijing Medical University, Beijing) (Nationas Research Laboratories of Natural and Biomimatic Drugs, Beijingmedicae Univerciy, Beijing)(Resarch Center of Standard Materials Chinese Academy of Metrological Science, Beijing |
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| Abstract: | To get an insight in the trigger mechanism of the pigment gallstone formation, the actions of active-oxygen free radical on bilirubin were studied in vitro. The results show that the·O2- and·OH may induce polymerization and aggregation of bilirubin, and the later transforms into a stable free radical which may cause lipid peroxidation of phospholipid and depolymerization of hyaluronic acid. The free radical treatrd bilirubin becomes less soluble and show much higher granular distribution. Based on these evidences, pathological process of a free radical mediated pigment gallstone is discussed. |
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| Keywords: | Bilirubin Pigment gallstone Free Radical |
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