Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism |
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| Authors: | Papkalla Armin Münch Jan Otto Claas Kirchhoff Frank |
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| Affiliation: | Institute for Clinical and Molecular Virology, University of Erlangen-Nürnberg, Germany. |
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| Abstract: | We investigated the infectivities and replicative capacities of a large panel of variants of the molecular human immunodeficiency virus type 1 (HIV-1) NL4-3 clone that differ exclusively in the V3 region of the viral envelope glycoprotein and the nef gene. Our results demonstrate that Nef enhances virion infectivity and HIV-1 replication independently of the viral coreceptor tropism. |
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