Theory of force regulation by nascent adhesion sites |
| |
Authors: | Bruinsma Robijn |
| |
Institution: | Department of Physics and Astronomy, University of California at Los Angeles, USA. bruinsma@physics.ucla.edu |
| |
Abstract: | The mechanical coupling of a cell with the extracellular matrix relies on adhesion sites, clusters of membrane-associated proteins that communicate forces generated along the F-Actin filaments of the cytoskeleton to connecting tissue. Nascent adhesion sites have been shown to regulate these forces in response to tissue rigidity. Force-regulation by substrate rigidity of adhesion sites with fixed area is not possible for stationary adhesion sites, according to elasticity theory. A simple model is presented to describe force regulation by dynamical adhesion sites. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|