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| RhoC和Ki67在非小细胞肺癌中的表达及意义 | |
| 引用本文： | 方长清,唐娜,杨青松,李淼,王业林,李建华.RhoC和Ki67在非小细胞肺癌中的表达及意义[J].中国组织化学与细胞化学杂志,2011,20(2):162-165. |
| 作者姓名： | 方长清 唐娜 杨青松 李淼 王业林 李建华 |
| 作者单位： | 1. 中国医科大学附属第一医院病理科及中国医科大学病理教研室,沈阳,110001 2. 抚顺市第四医院放射科,抚顺,113123 3. 辽宁中医药大学附属第二医院病理科,沈阳,110034 |
| 基金项目： | 辽宁省科学技术厅资助(20082077) |
| 摘 要： | 目的探讨RhoC、Ki67在非小细胞肺癌中的表达状况及其与临床病理学参数间的关系。方法利用免疫组织化学(ElivisionTMplus法),检测肺癌组织芯片中151例非小细胞肺癌患者RhoC、Ki67的表达情况。结果肺癌组织的RhoC蛋白阳性表达率为59.60%(90/151),相应癌旁组织RhoC阳性表达率为32.7%(16/49),差别有显著意义(P<0.05)。RhoC在TNMIII/IV期的NSCLC组织中阳性表达率为68.9%(51/74),明显高于在Ⅰ/II期NSCLC组织中阳性表达率50.6%(39/77,P<0.05);RhoC在出现淋巴结转移的表达率为49.2%(32/65),显著高于没有淋巴结转移的阳性表达率67.4%(58/86,P<0.05);非小细胞肺癌中RhoC高表达同Ki-67高表达呈显著正相关关系(χ2=21.634,r=0.377,P<0.01)。结论RhoC的高表达与非小细胞肺癌的分期,淋巴结转移及增殖有关。 |
| 关 键 词： | RhoC Ki67 非小细胞肺癌 侵袭转移 |
Expression and clinical significance of RhoC and ki-67 in non-small-cell lung cancer |
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| Fang Changqing,Tang Na,Yang Qingsong,Li Miao,Wang Yelin,Li Jianhua.Expression and clinical significance of RhoC and ki-67 in non-small-cell lung cancer[J].Chinese Journal of Histochemistry and Cytochemistry,2011,20(2):162-165. | |
| Authors: | Fang Changqing Tang Na Yang Qingsong Li Miao Wang Yelin Li Jianhua |
| Institution: | Fang Changqing,Tang Na,Yang Qingsong1,Li Miao2,Wang Yelin,Li Jianhua(Department of Pathology,China Medical University and Department of Pathology,The First Affiliated Hospital of China Medical University,Shenyang,110001,1 Department of Radiology,The Forth Hospital of Fushun,Fushun 113123,2 Department of Pathology,The Second Affiliated Hospital of Liaoning Tradition China Medical University,110034,China) |
| Abstract: | Objective To explore the expression and significance of RhoC,Ki-67 in non-smallcell lung cancer.Methods The expressions of RhoC and Ki-67 in 151 specimens of lung cancer were detected by immunohistochemistry in tissue microassay.Results The expression of RhoC was detected in 90 of the 151(59.60%) human lung cancer tissues,significantly higher than that in normal lung tissues,which was only in 16 of the 49 cases(32.7%).The positive expression of RhoC was higher in advanced TNM stages(III+IV) of NSCLC,than in... |
| Keywords: | RhoC Ki67 Non-smallcell lung cancer Invasiveness |
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