MetaTM - a consensus method for transmembrane protein topology prediction |
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Authors: | Martin Klammer David N Messina Thomas Schmitt and Erik LL Sonnhammer |
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Institution: | (1) Stockholm Bioinformatics Centre, Albanova, Stockholm University, 10691 Stockholm, Sweden |
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Abstract: | Background Transmembrane (TM) proteins are proteins that span a biological membrane one or more times. As their 3-D structures are hard
to determine, experiments focus on identifying their topology (i. e. which parts of the amino acid sequence are buried in
the membrane and which are located on either side of the membrane), but only a few topologies are known. Consequently, various
computational TM topology predictors have been developed, but their accuracies are far from perfect. The prediction quality
can be improved by applying a consensus approach, which combines results of several predictors to yield a more reliable result. |
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