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| TP、VEGF在结直肠癌中的表达及临床病理研究 | |
| 引用本文： | 夏传生,李娜萍,吴纯东,王义松,王书刚. TP、VEGF在结直肠癌中的表达及临床病理研究[J]. 中国组织化学与细胞化学杂志, 2011, 20(2): 182-186. DOI: 10.3870/zgzzhx.2011.02.016 |
| 作者姓名： | 夏传生 李娜萍 吴纯东 王义松 王书刚 |
| 作者单位： | 1. 解放军第457医院三病区,武汉,430012 2. 华中科技大学同济医学院附属同济医院病理研究所,武汉,430030 3. 解放军95825部队卫生队,湖北孝感,432111 |
| 摘 要： | 目的探讨胸苷磷酸化酶(TP)、血管内皮生长因子(VEGF)的表达及其与结直肠癌临床病理特征的关系。方法应用免疫组织化学EnVisionTM法检测88例结直肠癌组织中TP、VEGF的表达,结合临床病理特征进行分析。结果正常结直肠黏膜上皮不表达TP和VEGF;TP表达于结直肠癌细胞和(或)间质内单个核细胞,VEGF表达于癌细胞。TP和VEGF的阳性表达率分别为42.05%(37/88)和23.86%(21/88)。TP和VEGF在淋巴结转移及Duke’sⅢ-Ⅳ期患者中的阳性率高于无淋巴结转移及Duke’sⅠ-Ⅱ期患者(P<0.05);TP阳性表达率在癌组织浸润至浆膜及浆膜外组高于浸润程度较浅组(P<0.05)。结论TP和VEGF的异常表达可能促进结直肠癌的浸润与转移。 |
| 关 键 词： | 结直肠癌 TP VEGF 预后 |
The expression of TP,VEGF and its relationship with clinical Pathological significance in Colorectal Cancer |
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| Xia Chuansheng,Li Naping,Wu Chundong,Wang Yishong,Wang Shugang. The expression of TP,VEGF and its relationship with clinical Pathological significance in Colorectal Cancer[J]. Chinese Journal of Histochemistry and Cytochemistry, 2011, 20(2): 182-186. DOI: 10.3870/zgzzhx.2011.02.016 | |
| Authors: | Xia Chuansheng Li Naping Wu Chundong Wang Yishong Wang Shugang |
| Affiliation: | Xia Chuansheng,Li Naping1,Wu Chundong,Wang Yishong,Wang Shugang2(The Third Dept,NO.457 Hospital of People's Liberation Army,Wuhan 430012,1Department of Pathology,Tong Ji Hospital,Tong Ji Medical College,Huazhong University of Science and Technology,Wuhan 4300302NO.95825 Army Sanitation Band of People's Liberation Army,Hubei Xiaogan 432111,China) |
| Abstract: | Objective To investigate the expression of thymidine phosphorylase(TP) and vascular endothelial growth factor(VEGF) and its relationship with clinical pathological charucteristies of colorectal cancer.Methods Immunohistochemical staining method EnVision TM was used to investigate the expression of TP and VEGF in 88 cases of colorectal cancer and its relationship with clinical pathology.Results TP and VEGF were not expressed in normal colorectal mucosa,but TP expression in cancer tissue was observed in both ... |
| Keywords: | Colorectal Cancer TP VEGF Prognosis |
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