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Human Endogenous Retrovirus Type W Envelope from Multiple Sclerosis Demyelinating Lesions Shows Unique Solubility and Antigenic Characteristics |
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| Authors: | Charvet Benjamin Pierquin Justine Brunel Joanna Gorter Rianne Quétard Christophe Horvat Branka Amor Sandra Portoukalian Jacques Perron Hervé |
| Institution: | 1.GeNeuro Innovation, Lyon, 69008, France ;2.CIRI, International Center for Infectiology Research, INSERM U1111, CNRS UMR5308, University of Lyon, ENS Lyon, France ;3.Université Claude Bernard Lyon 1, Lyon, 69000, France ;4.Department of Pathology, Amsterdam UMC, Location VUMC, 1007 MB, Amsterdam, The Netherlands ;5.ProteinSimple, Abingdon, OX14 3NB, UK ;6.Centre for Neuroscience and Trauma, Blizard Institute, Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK ; |
| Abstract: | Virologica Sinica - In multiple sclerosis (MS), human endogenous retrovirus W family (HERV-W) envelope protein, pHERV-W ENV, limits remyelination and induces microglia-mediated neurodegeneration.... |
| Keywords: | Multiple sclerosis (MS) Brain Antigen HERV-W Envelope Endogenous retrovirus MSRV-ENV Syncytin Demyelination Lipids Glycolipids Sulfatides Oligomer Hexamer |
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