High Frequency of Herpesvirus-Specific Clonotypes in the Human T Cell Repertoire Can Remain Stable over Decades with Minimal Turnover |
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| Authors: | M. A. Neller J. M. Burrows M. J. Rist J. J. Miles S. R. Burrows |
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| Affiliation: | aAustralian Centre for Vaccine Development, Queensland Institute of Medical Research, Brisbane, Australia;bSchool of Medicine, The University of Queensland, Brisbane, Australia;cInstitute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom |
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| Abstract: | High-throughput T cell receptor sequencing on sequentially banked blood samples from healthy individuals has shown that high-frequency clonotypes can remain relatively stable for up to 18 years, with minimal inflation, deflation, or turnover. These populations included T cell expansions specific for Epstein-Barr virus. Thus, in spite of exposure to a barrage of microorganisms over the course of life, the dominant clonotypes in the mature peripheral T cell repertoire can alter surprisingly little. |
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