Clinical Characteristics of Hospitalized Patients with SARS-CoV-2 and Hepatitis B Virus Co-infection |
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Authors: | Chen Xiaoping Jiang Qunqun Ma Zhiyong Ling Jiaxin Hu Wenjia Cao Qian Mo Pingzheng Yao Lei Yang Rongrong Gao Shicheng Gui Xien Hou Wei Xiong Yong Li Jinlin Zhang Yongxi |
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Institution: | 1.Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China ;2.Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, University of Uppsala, 75123, Uppsala, Sweden ;3.State Key Laboratory of Virology/Institute of Medical Virology/Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China ;4.Department of Cell and Molecular Biology, Karolinska Institute, 17165, Stockholm, Sweden ; |
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Abstract: | In addition to the recent emerged SARS-CoV-2, hepatitis B virus (HBV) is one of the viruses which cause a global infection and threat public health. In worldwide, the prevalence of HBsAg is about 3.9% (Polaris Observatory 2018). According to a nationwide epidemiological survey of population whose ages range from 1 to 59 years in China, 2006, the prevalence of HBsAg was 7.2% (Liang et al. 2009). As SARS-CoV-2 and HBV both can cause liver damage (Fan et al. 2020), further understanding of the risk of SARS-CoV-2 on patients with HBV infection is urgently required in order to design an optimized treatment strategy. However, the impacts of SARS-CoV-2 infection on HBV patients are still not clear. For example, we do not yet know whether the SARS-CoV-2 infection is more severe in HBV patients and we also do not have much knowledge about the impact of SARS-CoV-2 on the course of HBV infection. In this retrospective study, we investigated the clinical characterizes of the patients coinfected with SARS-CoV-2 and HBV by analyzing the clinical records and laboratory tests of 123 COVID-19 patients admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from January 5 to February 20, 2020. |
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