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Antigenic Drift of the Hemagglutinin from an Influenza A (H1N1) pdm09 Clinical Isolate Increases its Pathogenicity In Vitro |
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| Authors: | Xing Lei Chen Yunbo Chen Boqian Bu Ling Liu Ying Zeng Zhiqi Guan Wenda Chen Qigao Lin Yongping Qin Kun Chen Honglin Deng Xilong Wang Xinhua Song Wenjun |
| Institution: | 1.State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510180, China ;2.Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China ;3.Institute of Integration of Traditional and Western Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510180, China ;4.Intensive Care Unit, Guangzhou No.8 People’s Hospital of Guangzhou Medical University, Guangzhou, 510060, China ;5.State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China ;6.China CDC, National Institute for Viral Disease Control and Prevention, Beijing, 100052, China ; |
| Abstract: | Virologica Sinica - The influenza A (H1N1) pdm09 virus emerged in 2009 and has been continuously circulating in humans for over ten years. Here, we analyzed a clinical influenza A (H1N1)... |
| Keywords: | HA antigenic drift Influenza A (H1N1) pdm09 virus HA epitope Sb |
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