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Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts
Affiliation:1. Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA;2. Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA;3. Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA;4. Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, TN 37232, USA;5. Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA;6. Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, MD 21201, USA;7. Department of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA 90089, USA;8. Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA;9. Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA;10. National Heart, Lung, and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA 01702, USA;11. Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA 98101, USA;12. Department of Medicine, Division of Pulmonary, Critical Care & Sleep Medicine, National Jewish Health, Denver, CO 80206, USA;13. Department of Medicine, Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115, USA;14. Department of Medicine, Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA;15. Macrogen USA, Rockville, MD 20850, USA;16. Department of Medicine, Division of Pulmonary and Critical Care, University of Iowa, Iowa City, IA 52242, USA;17. Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA;18. Illumina Laboratory Services, Illumina Inc., San Diego, CA 92122, USA;19. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA;20. Department of Pathology & Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05446, USA;21. Department of Biostatistics, University of Washington, Seattle, WA 98195, USA;22. GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;23. Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;24. Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA;25. Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA;26. Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD 21201, USA;27. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA;28. Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA;29. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA;30. Department of Biochemistry, Larner College of Medicine, University of Vermont, Burlington, VT 05446, USA;31. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA;32. School of Public Health, University of Washington, Seattle, WA 98195, USA;33. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA;34. Department of Statistics, Harvard University, Cambridge, MA 02138, USA;35. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA;36. Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA;37. Department of Epidemiology, University of Washington, Seattle, WA 98195, USA;38. Joseph J. Zilber School of Public Health, University of Wisconsin Milwaukee, Milwaukee, WI 53205, USA
Abstract:
Keywords:whole-genome sequencing  c-reactive protein
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