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Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups
Affiliation:1. Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA;2. Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA;3. Department of Biomedical Informatics, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212, USA;4. Schools of Medicine, Public Health, and Nursing, Johns Hopkins University, Baltimore, MD 21205, USA;5. Irving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, NY 10032, USA;6. Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212, USA;7. Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA;8. Department of Medicine, University of Washington, Seattle, WA 98195, USA;9. Geisinger, Danville, PA 17822, USA;10. Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;11. National Human Genome Research Institute, Bethesda, MD 20892, USA;12. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Abstract:
Keywords:risk prediction  polygenic risk scores  multiethnic  ischemic heart disease  coronary heart disease  coronary artery disease  African American  hispanic  genome-wide polygenic score
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