Identification of genes differentially expressed in wild type and Purkinje cell degeneration mice |
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Authors: | Xiao Rui Park Youngsook Dirisala Vijaya R Zhang Ya-Ping Um Sang June Lee Hoon Taek Park Chankyu |
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Institution: | Department of Animal Biotechnology; Bio-Organ Research Center/Institute of Biomedical Science and Technology, Konkuk University, Seoul 143-701, Korea. |
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Abstract: | Purkinje cell degeneration (pcd) mice are characterized by death of virtually all cerebellar Purkinje cells by postnatal day 30. In this study, we used DNA microarray analysis to investigate differences in gene expression between the brains of wild type and pcd mice on postnatal day 20, before the appearance of clear-cut phenotypic abnormalities. We identified 300 differentially expressed genes, most of which were involved in metabolic and physiological processes. Among the differentially expressed genes were several calcium binding proteins including calbindin-28k, paravalbumin, matrix gamma-carboxyglutamate protein and synaptotagamins 1 and 13, suggesting the involvement of abnormal Ca2+ signaling in the pcd phenotype. |
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