Quantification of biomechanical properties of human corneal scar using acoustic radiation force optical coherence elastography |
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Authors: | Xiao Han Yubao Zhang Yirui Zhu Yanzhi Zhao Hongwei Yang Guo Liu Sizhu Ai Yidi Wang Chengfeng Xie Jiulin Shi Tianyu Zhang Guofu Huang Xingdao He |
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Institution: | 1.Key Laboratory of Opto-Electronic Information Science and Technology of Jiangxi Province and Jiangxi Engineering Laboratory for Optoelectronics Testing Technology, Nanchang Hangkong University, Nanchang 330063, P. R. China; 2.The Third Affiliated Hospital of Nanchang University, Nanchang 330008, P. R. China; 3.Key Laboratory of Geophysical Exploration Equipment, Ministry of Education, College of Instrumentation & Electrical Engineering, Jilin University, Changchun 130012, P. R. China |
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Abstract: | Biomechanical properties of corneal scar are strongly correlated with many corneal diseases and some types of corneal surgery, however, there is no elasticity information available about corneal scar to date. Here, we proposed an acoustic radiation force optical coherence elastography system to evaluate corneal scar elasticity. Elasticity quantification was first conducted on ex vivo rabbit corneas, and the results validate the efficacy of our system. Then, experiments were performed on an ex vivo human scarred cornea, where the structural features, the elastic wave propagations, and the corresponding Young’s modulus of both the scarred region and the normal region were achieved and based on this, 2D spatial distribution of Young’s modulus of the scarred cornea was depicted. Up to our knowledge, we realized the first elasticity quantification of corneal scar, which may provide a potent tool to promote clinical research on the disorders and surgery of the cornea. |
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Keywords: | Optical coherence tomography optical coherence elastography acoustic radiation force biomechanical properties cornea corneal scar |
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