Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-α and matrix metalloproteinase-13 in human chondrocytes |
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| Authors: | Zafar Rasheed Arivarasu N Anbazhagan Nahid Akhtar Sangeetha Ramamurthy Frank R Voss and Tariq M Haqqi |
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| Institution: | (1) Department of Pathology, Microbiology, & Immunology, School of Medicine, University of South Carolina, 6439 Garners Ferry Rd, Columbia, SC 29209, USA;(2) Department of Orthopaedics, University of South Carolina, School of Medicine/Palmetto Richland Hospital, Two Medical Park, Columbia, SC 29209, USA |
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| Abstract: | Introduction The major risk factor for osteoarthritis (OA) is aging, but the mechanisms underlying this risk are only partly understood.
Age-related accumulation of advanced glycation end products (AGEs) can activate chondrocytes and induce the production of
proinflammatory cytokines and matrix metalloproteinases (MMPs). In the present study, we examined the effect of epigallocatechin-3-gallate
(EGCG) on AGE-modified-BSA (AGE-BSA)-induced activation and production of TNFα and MMP-13 in human OA chondrocytes. |
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