Molecular Characterization of the Klebicin B Plasmid of Klebsiella pneumoniae |
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Authors: | Margaret A Riley Theodora Pinou John E Wertz Yin Tan Carla M Valletta |
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Institution: | Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, 06520 |
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Abstract: | The nucleotide sequence of a bacteriocin-encoding plasmid isolated from Klebsiella pneumoniae (pKlebB-K17/80) has been determined. The encoded klebicin B protein is similar in sequence to the DNase pyocins and colicins, suggesting that klebicin B functions as a nonspecific endonuclease. The klebicin gene cluster, as well as the plasmid backbone, is a chimera, with regions similar to those of pore-former colicins, nuclease pyocins and colicins as well as noncolicinogenic plasmids. Similarities between pKlebB plasmid maintenance functions and those of the colicin E1 plasmid suggest that pKlebB is a member of the ColE1 plasmid replication family. |
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Keywords: | bacteriocin klebicin evolution colicin plasmid |
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