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Structure--function studies on selectin carbohydrate ligands. Modifications to fucose, sialic acid and sulphate as a sialic acid replacement |
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| Authors: | Brandley, Brian K. Kiso, Makoto Abbas, Saeed Nikrad, Pandarung Srivasatava, Om Foxall, Carrol Oda, Yuko Hasegawa, Akira |
| Affiliation: | Glycomed, Inc., 860 Atlantic Avenue Alameda, CA 94501, USA 1Alberta Research Council, Edmonton, Alberta T6H 5X2, Canada 2Department of Bioorganic Chemistry, Gifu University Gifu, 501-11, Japan |
| Abstract: | The selectins are a family of carbohydrate-binding proteinsthat have been implicated in the initial interaction betweenleukocytes and the vascular endothelium. The three members ofthis family will bind to the sialyl-Lewisx epitope [Sia |
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