| 综述: 组蛋白变体的染色质组装 |
| |
| 引用本文： | 周驹俊,冯晓利,周政.综述: 组蛋白变体的染色质组装[J].生物化学与生物物理进展,2015,42(11):1003-1008. |
| |
| 作者姓名： | 周驹俊 冯晓利 周政 |
| |
| 作者单位： | 中国科学院生物物理研究所，生物大分子国家重点实验室，北京 100101；中国科学院大学研究生院，北京 100049,中国科学院生物物理研究所，生物大分子国家重点实验室，北京 100101,中国科学院生物物理研究所，生物大分子国家重点实验室，北京 100101 |
| |
| 基金项目： | 国家自然科学基金(31521002, 31270833)和国家重点基础研究发展计划(973)(2013CB910203, 2015CB856202)资助项目. 本文通讯作者为国家青年千人计划入选者，中科院-诺和诺德长城教授 |
| |
| 摘 要： | 真核细胞的染色质组装是组蛋白和DNA有序地形成核小体和染色质的过程．通过调节DNA的开放或折叠状态，染色质组装不但影响遗传信息的编码和存储，也决定了遗传信息的提取和解读．作为染色质组装的重要调控因子，组蛋白变体和组蛋白伴侣在与DNA相关的生命活动进程中发挥着至关重要的作用．本文综述了组蛋白变体H2A.Z以及CENP-A进行染色质组装的研究进展，并着重讨论了组蛋白变体和组蛋白伴侣在染色质组装中的重要作用．
|
| 关 键 词： | 染色质组装，组蛋白变体，组蛋白伴侣 |
| 收稿时间： | 8/7/2015 12:00:00 AM |
| 修稿时间： | 8/7/2015 12:00:00 AM |
Review: Chromatin Assembly of Histone Variants |
| |
| ZHOU Ju-Jun,FENG Xiao-Li and ZHOU Zheng.Review: Chromatin Assembly of Histone Variants[J].Progress In Biochemistry and Biophysics,2015,42(11):1003-1008. |
| |
| Authors: | ZHOU Ju-Jun FENG Xiao-Li and ZHOU Zheng |
| |
| Institution: | National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China,National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China |
| |
| Abstract: | Chromatin assembly in eukaryote is a well-organized process in which DNA and histone are hierarchically packaged into the nucleosome and chromatin. The assembly and disassembly of chromatin decode the genetic information stored within the chromatin. Histone variant and histone chaperone are major players in regulating the chromatin assembly and virtually involve in all DNA-based processes. In this review, we discuss the recent findings that provide insights into the assembly mechanism of histone variant H2A.Z and CENP-A, and highlight the important roleshistone chaperones play in this process. |
| |
| Keywords: | chromatin assembly histone variant histone chaperone |
|
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
| 点击此处可从《生物化学与生物物理进展》下载免费的PDF全文 |
