综述: DNA甲基化在动物胚胎和生殖细胞发育过程中的重编程

表观遗传信息DNA甲基化在动物的发育、细胞分化和器官形成过程中，起着至关重要的作用．近期，关于DNA甲基化在脊椎动物胚胎发育和生殖细胞发育过程重编程的研究取得了重要的进展．发现斑马鱼的早期胚胎完整地继承了精子的DNA甲基化图谱，而哺乳动物的早期胚胎和原始生殖细胞发育过程则经历了整体去甲基化并重新建立甲基化图谱的过程，但胚胎发育过程中基因的印迹区未发生DNA去甲基化，而生殖细胞发育过程中印迹区的甲基化修饰被消除．

Review: The Programming of DNA Methylation During Vertebrate Embryogenesis and Gametogenesis

5-Methylcytosine is one major epigenetic modification which plays critical roles during development, cell differentiation and organogenesis. Recently, remarkable progress has been achieved in understanding the programming and inheritance of DNA methylation during early embryogenesis and gametogenesis in vertebrates. Studies have revealed that sperm DNA methylome can be stably inherited by early embryos in zebrafish. However, both paternal and maternal methylomes undergo dramatic demethylation and reprogramming during mammalian embryogenesis and germ cell development. Most germ-line imprinting control regions escape from demethylation during mammalian embryogenesis, but these regions are demethylated during primordial germ cell development.