Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys |
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| Authors: | Permar Sallie R Klumpp Sherry A Mansfield Keith G Kim Woong-Ki Gorgone Darci A Lifton Michelle A Williams Kenneth C Schmitz Jörn E Reimann Keith A Axthelm Michael K Polack Fernando P Griffin Diane E Letvin Norman L |
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| Institution: | Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. |
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| Abstract: | The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8(+) cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8(+) lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus. The CD8(+) lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals. These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies. |
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