Synthetic corticotropin-releasing factor stimulates secretion of immunoreactive beta-endorphin/beta-lipotropin and ACTH by human fetal pituitaries in vitro |
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| Authors: | D M Gibbs R D Stewart W Vale J Rivier S S Yen |
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| Institution: | 1. Department of Reproductive Medicine (T-002), UCSD School of Medicine, La Jolla, CA 92093, USA;2. Peptide Biology Laboratory (W.V., J.R.), The Salk Institute, La Jolla, CA 92138, USA |
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| Abstract: | Synthetic ovine CRF, in an amount approximating that found in pituitary portal plasma of the rat, induced a significant increase in the secretion of both ACTH and immunoreactive beta-endorphin/beta-LPH (i beta-END/LPH) by human fetal hemipituitaries in an in vitro superfusion system. This finding suggests that a molecule similar to synthetic ovine CRF may be a physiologic hypothalamic releasing factor in man. |
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