The Andes hantavirus NSs protein is expressed from the viral small mRNA by a leaky scanning mechanism |
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| Authors: | Vera-Otarola Jorge Solis Loretto Soto-Rifo Ricardo Ricci Emiliano P Pino Karla Tischler Nicole D Ohlmann Théophile Darlix Jean-Luc López-Lastra Marcelo |
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| Affiliation: | Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Centro de Investigaciones Médicas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. |
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| Abstract: | The small mRNA (SmRNA) of all Bunyaviridae encodes the nucleocapsid (N) protein. In 4 out of 5 genera in the Bunyaviridae, the smRNA encodes an additional nonstructural protein denominated NSs. In this study, we show that Andes hantavirus (ANDV) SmRNA encodes an NSs protein. Data show that the NSs protein is expressed in the context of an ANDV infection. Additionally, our results suggest that translation initiation from the NSs initiation codon is mediated by ribosomal subunits that have bypassed the upstream N protein initiation codon through a leaky scanning mechanism. |
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