Synthesis and antiproliferative activity of some steroidal lactone compounds |
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Authors: | Gan Chunfang Cui Jianguo Huang Yanmin Jia Linyi Wei Wanxin |
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Affiliation: | School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530022, China. |
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Abstract: | Using cholesterol as starting material, some steroidal lactone compounds with the structures of 3-substituted-6-oxo-7-oxa-B-homo-cholestane or 3-substituted-7-oxo-6-oxa-B-homo-cholestane were synthesized by oxidation, reduction, Baeyer-Villiger reaction and condensation reaction. The cytotoxicity of these compounds against MGC 7901 (human gastric carcinoma), HeLa (human cervical carcinoma) and SMMC 7404 (human liver carcinoma) cells was investigated. Our results showed that the synthesized compounds displayed a distinct cytotoxicity against these cancer cells. In particular, compounds 8 and 9 have similar cytotoxic capability as cisplatin does. The information obtained from the studies may be useful for the design of novel chemotherapeutic drugs. |
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