Identification of boronic acids as antagonists of bacterial quorum sensing in Vibrio harveyi |
| |
| Authors: | Ni Nanting Chou Han-Ting Wang Junfeng Li Minyong Lu Chung-Dar Tai Phang C Wang Binghe |
| |
| Institution: | a Department of Chemistry, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30302-4098, USA
b Department of Biology, Georgia State University, Atlanta, GA 30302-4010, USA |
| |
| Abstract: | Bacterial quorum sensing plays a very important role in the regulation of biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are important research tools and potential therapeutic agents. In this paper, we describe for the first time the discovery of several boronic acids as single digit micromolar inhibitors of bacterial quorum sensing in Vibrio harveyi. |
| |
| Keywords: | Quorum sensing Autoinducer-2 (AI-2) Boronic acids Inhibitors |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
