Protective Effects of Adeno-associated Virus Mediated Brain-derived Neurotrophic Factor Expression on Retinal Ganglion Cells in Diabetic Rats |
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| Authors: | Yan Gong Zhan-Ping Chang Ruo-Tong Ren Shi-hui Wei Huan-Fen Zhou Xiao-fei Chen Bao-ke Hou Xin Jin Mao-nian Zhang |
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| Affiliation: | (1) Department of Ophthalmology, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, 100853 Beijing, China;(2) Department of Pathology, Aerospace 731 Hospital, Beijing, China;(3) Institute of Biophysics, Chinese Academy of Sciences, Beijing, China;(4) Department of Ophthalmology, The First Affiliated Hospital of General Hospital of PLA, Beijing, China; |
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| Abstract: | Adeno-associated virus vector plasmid carrying the expression cassette of brain-derived neurotrophic factor (BDNF), pAAV-BDNF, was constructed and packaged into recombinant adeno-associated virus (rAAV-BDNF). The rAAV-BDNF was intravitreally injected into streptzotocin (STZ)-induced diabetic Sprague–Dawley (SD) Rats. Data showed that over-expression of BDNF could increase alive retinal ganglion cell (RGC) number and improve its function in streptzotocin(STZ)-induced diabetic rats, which might be a new method to treat diabetic neuropathy and retinopathy. |
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