Interactions of putative heparin-binding domains of basic fibroblast growth factor and its receptor, FGFR-1, with heparin using synthetic peptides |
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| Authors: | Lisa Kinsella Hai-Lan Chen John A Smith Philip S Rudland David G Fernig |
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| Affiliation: | (1) Cancer and Polio Research Fund Laboratories, School of Biological Sciences, Life Sciences Building, PO Box 147, Liverpool, L69 7ZB, UK |
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| Abstract: | We have examined structure-function relationships that have been proposed to account for the heparin-binding properties of basic fibroblast growth factor and its receptor, FGFR-1, using synthetic peptides, DNA synthesis assays and binding assays in a resonant mirror biosensor. The results suggest that the interaction of FGFR-1 with heparin may not be physiologically relevant and that the site of interaction of the polysaccharide on bFGF is more complex than has been anticipated. © 1998 Rapid Science Ltd |
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| Keywords: | fibroblast growth factor FGFR-1 heparin synthetic peptides |
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