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Replication of association between ELAVL4 and Parkinson disease: the GenePD study |
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| Authors: | Anita L. DeStefano Jeanne Latourelle Mark F. Lew Oksana Suchowersky Christine Klein Lawrence I. Golbe Margery H. Mark John H. Growdon G. Fredrick Wooten Ray Watts Mark Guttman Brad A. Racette Joel S. Perlmutter Lynn Marlor Holly A. Shill Carlos Singer Stefano Goldwurm Gianni Pezzoli Marie H. Saint-Hilaire Audrey E. Hendricks Adam Gower Sally Williamson Michael W. Nagle Jemma B. Wilk Tiffany Massood Karen W. Huskey Kenneth B. Baker Ilia Itin Irene Litvan Garth Nicholson Alastair Corbett Martha Nance Edward Drasby Stuart Isaacson David J. Burn Patrick F. Chinnery Peter P. Pramstaller Jomana Al-hinti Anette T. Moller Karen Ostergaard Scott J. Sherman Richard Roxburgh Barry Snow John T. Slevin Franca Cambi James F. Gusella Richard H. Myers |
| Affiliation: | Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Crosstown Center, 3rd floor, Boston, MA 02118, USA. adestef@bu.edu |
| Abstract: | Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. In the current study we genotyped three single nucleotide polymorphisms in ELAVL4 in a Caucasian study sample consisting of 712 PD patients and 312 unrelated controls from the GenePD study. The minor allele of rs967582 was associated with increased risk of PD (odds ratio = 1.46, nominal P value = 0.011) in the GenePD population. The minor allele of rs967582 was also the risk allele for PD affection or earlier onset age in the previously studied populations. This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene. |
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