Design and semisynthesis of novel fredericamycin A derivatives with an improved antitumor profile |
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Authors: | Abel Ulrich Simon Werner Eckard Peter Hansske Friedrich G |
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Affiliation: | Santhera Pharmaceuticals, Im Neuenheimer Feld 518-519, 69120 Heidelberg, Germany. |
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Abstract: | We report the design, semisynthesis, and biological activity of a series of fredericamycin (1) derivatives. Within this series compound 1e combines low nanomolar cytotoxic potency in vitro, increased tumor cell line selectivity, and in vivo activity in a human xenograft model. |
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