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An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum |
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| Authors: | Evans Liam Hedger John N Brayford David Stavri Michael Smith Eileen O'Donnell Gemma Gray Alexander I Griffith Gareth W Gibbons Simon |
| Institution: | Hypha Discovery Ltd., School of Biosciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK. |
| Abstract: | A fusidane triterpene, 16-deacetoxy-7-beta-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all (1)H and (13)C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra. Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 microg/ml. |
| Keywords: | Acremonium crotocinigenum Fusidane triterpene Fusidic acid Antibacterial MRSA MDR Staphylococcus aureus |
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