Modeling of glycolytic wave propagation in an open spatial reactor with inhomogeneous substrate influx |
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Authors: | AI Lavrova S Bagyan T Mair MJB Hauser L Schimansky-Geier |
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Institution: | 1. Institute of Physics, Humboldt-University at Berlin, Newtonstr. 15, D-12489 Berlin, Germany;2. Institute of Experimental Physics,Biophysics Group, Otto-von-Guericke-University Magdeburg, Universitätsplatz 2, D-39106 Magdeburg, Germany |
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Abstract: | The spatio-temporal dynamics of traveling waves in glycolysis as it occurs in yeast extract have been studied, both theoretically and experimentally. We describe this phenomenon with the distributed Selkov model that accounts for the reactions of phosphofructokinase, which is a key enzyme of the glycolytic reaction cascade. To describe the experimentally observed phase waves in an open spatial reactor we introduce a non-homogeneous flux of substrate in the model. The experimental observation that waves can change their direction of propagation during the experiment is considered in the model. The mechanism for such a change in wave direction is discussed. |
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Keywords: | Glycolytic oscillations Selkov model Spatio-temporal dynamics |
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