| 磷酸肌酸对豚鼠心肌细胞缺氧复氧损伤膜电位的影响 |
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| 引用本文： | 李芳,孙明智.磷酸肌酸对豚鼠心肌细胞缺氧复氧损伤膜电位的影响[J].中国应用生理学杂志,1996,12(4):305-308. |
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| 作者姓名： | 李芳 孙明智 |
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| 作者单位： | 哈尔滨医科大学生理学教研室 病理生理教研室 |
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| 摘 要： | 本实验观察了缺氧复氧对豚鼠心肌细胞膜电位的影响及磷酸肌酸的保护作用。结果表明缺氧５－２０ｍｉｎ时ＲＰ、ＡＰＡ减小，Ｖｍａｘ减慢，ＡＰＤ１０、ＡＰＤ５０、ＡＰＤ９０缩短。复氧５－２０ｍｉｎ后，ＲＰ、ＡＰＡ和Ｖｍａｘ进一步减少，ＡＰＤ１０、ＡＰＤ５０、ＡＰＤ９０明显缩短。在灌流液中加入磷酸肌酸保持其浓度在１０－６ｍｏｌ时，ＲＰ、ＡＰＡ显著增加，Ｖｍａｘ增快，ＡＰＤ１０、ＡＰＤ５０、ＡＰＤ９０明显延长。复氧２０ｍｉｎ后膜电位各项参数趋向恢复正常。此结果提示，磷酸肌酸对缺氧复氧的心肌具有显著的保护作用。
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| 关 键 词： | 心肌细胞 动作电位 缺氧复氧 磷酸肌酸 |
EFFECTOFPHOSPHOCREATINEONTRANSMEMBRANEPOTENTIALSINPAPILLARYMYOCARDIALCELLSOFGUINEAPIGUNDERANOXIAANDREOXYGENATIONINJURY |
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| LiFangSunMingzhiWangXiaomingXuChangqing.EFFECTOFPHOSPHOCREATINEONTRANSMEMBRANEPOTENTIALSINPAPILLARYMYOCARDIALCELLSOFGUINEAPIGUNDERANOXIAANDREOXYGENATIONINJURY[J].Chinese Journal of Applied Physiology,1996,12(4):305-308. |
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| Authors: | LiFangSunMingzhiWangXiaomingXuChangqing |
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| Institution: | LiFangSunMingzhiWangXiaoming1XuChangqing1 |
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| Abstract: | Theefectofanoxiaandreoxygenationontransmembranepotentialsinpapilarymyocardialcelsofguineapigandtheprotectiveefectofphosphocreatinewerestudied.TheresultsshowedthatRP,APAandVmaxweredecreased,APD10,APD50andAPD90wereshortenedmarkedlywhenanoxiacontinued5-20min.Altheparametersmentionedabovewerefurtherloweredafterreoxygenationfor5-20min.Phosphocreatineof10-6mol/LapparentlyincreasedRP,APA,VmaxandprolongedAPD10,APD50andAPD90,whichreturnedtonormalafterreoxygenating20min.Itisindicatedthatphosphocreatinemayposesprotectiveefectonanoxicandreoxygenatedpapilarymyocardium. |
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| Keywords: | myocardial actionpotential anoxiaandreoxygenation phosphocreatine |
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