| 海马脑片缺氧损伤电位机制的研究 |
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| 引用本文： | 唐建民,刘振伟,等.海马脑片缺氧损伤电位机制的研究[J].中国应用生理学杂志,1996,12(2):165-169. |
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| 作者姓名： | 唐建民 刘振伟 |
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| 作者单位： | 北京军事医学科学院基础医学研究所，大庆职工医学院病理生理教研室 |
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| 基金项目： | 国家自然科学基金，中国科学院低氧生理开放实验室资助 |
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| 摘 要： | 本实验在海马脑片采用微电极记录技术，观察了缺氧损伤电位（ＨＩＰ）的电生理特性，并研究了其产生机制。实验结果表明：①ＨＩＰ是突触在缺氧过程中功能暂时恢复的反应；②随着缺氧程度的加重，ＨＩＰ出现时间前移，持续时间缩短；③ＨＩＰ的出现表明突触功能的丧失发生在突触膜损伤之前，其消失代表突触传递不可逆性损伤的发生，即突触膜损伤的开始；④大剂量腺苷不能阻止ＨＩＰ的产生，表明ＨＩＰ的出现不是由于腺苷浓度的降低。
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| 关 键 词： | 海马脑片，缺氧，缺氧损伤电位，腺苷 |
MECHANISMS OF HYPOXIC INJURYPOTENTIAL IN HIPPOCAMPALSLICES |
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| Tang Jianmin,Liu Zhenwei,Ding Aishi,Wang Fuzhuang.MECHANISMS OF HYPOXIC INJURYPOTENTIAL IN HIPPOCAMPALSLICES[J].Chinese Journal of Applied Physiology,1996,12(2):165-169. |
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| Authors: | Tang Jianmin Liu Zhenwei Ding Aishi Wang Fuzhuang |
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| Abstract: | Electrical properties and mechanisms of hypoxic injury potential(HIP)were studied in areaCA1 pyramidaI neurons from rat hippocampal slices by means of microelectrode technique,Theresults indicated that(1)HIP was a transient recovery of synaptic function during hypoxia;(2)HIP occurred earlier and its duration was shortened when hypoxia was aggravated;(3)thesynaptic membrane was not damaged by hypoxia untiI HIP disappeared;(4) high dose ofadenosine failed to block the appearance of HIP,indicating that the reduction of adenosine didnot account for the appearance of HIP. |
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| Keywords: | hippocampal slice hypoxia hypoxic injury patential adenosine(Department of Pathophysiology Daqing Workers'Medical College Daqing 163312) |
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