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Resolution of DL-2-aminosuberic acid via protease-catalyzed ester hydrolysis |
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| Authors: | M Rivard P Maloň Dr V ?e?ovský |
| Institution: | (1) Laboratoires des Reactions Organiques Selectives, bat. 420, Université Paris-Sud, Orsay, France;(2) Insitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo 2, 166 10 Prague 6, Czech Republic |
| Abstract: | Summary Papain-catalyzed regioselective cleavage of -methyl ester in Z-DL-Asu(OMe)-OMe leads to Z-L-Asu(OMe)-OH and Z-D-Asu(OMe)-OMe. Subsequent saponifications yield Z-L-Asu-OH and Z-D-Asu-OH. The enzymatic-ester hydrolysis was also achieved by subtilisin BPN in organic solvent with low water content.Abbreviations Asu
2-aminosuberic acid
- Z
benzyloxycarbonyl
- OMe
methyl ester
- DCHA
dicyclohexylamine |
| Keywords: | Amino acids Aminosuberic acid Enzymatic resolution Papain Subtilisin |
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