The talin wags the dog: new insights into integrin activation |
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Authors: | Cram Erin J Schwarzbauer Jean E |
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Affiliation: | Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA. |
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Abstract: | Integrin transmembrane receptors have a unique property that distinguishes them from other signaling receptors. Their affinity for ligands can be modulated from the inside out in response to intracellular signals generated by non-integrin receptors. Recent findings provide novel mechanistic insights into this process by demonstrating that talin, a protein that links integrins to actin, is necessary for the inside-out activation of integrins. |
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