| 放线菌工业菌种选育、过程优化与放大研究进展 |
| |
| 引用本文： | 于岚,郭美锦,储炬,庄英萍,张嗣良.放线菌工业菌种选育、过程优化与放大研究进展[J].微生物学通报,2013,40(10):1810-1821. |
| |
| 作者姓名： | 于岚 郭美锦 储炬 庄英萍 张嗣良 |
| |
| 作者单位： | 1. 华东理工大学 生物反应器工程国家重点实验室 上海 200237;1. 华东理工大学 生物反应器工程国家重点实验室 上海 200237;1. 华东理工大学 生物反应器工程国家重点实验室 上海 200237;1. 华东理工大学 生物反应器工程国家重点实验室 上海 200237;1. 华东理工大学 生物反应器工程国家重点实验室 上海 200237 |
| |
| 基金项目： | 国家863计划项目(No. 2012AA021201); 湖州市南太湖特聘专家计划项目 |
| |
| 摘 要： | 放线菌属由于能够产生一系列结构复杂的生物活性物质而受到广泛关注, 这些活性代谢产物的大规模发酵生产在医药、农业等领域的应用中起着重要的作用。本文综述了近年来放线菌次级代谢产物产业化研究的一些新进展, 包括菌株的改造、生物过程优化和控制以及发酵放大技术, 并对这些方法和技术进行了讨论。
|
| 关 键 词： | 放线菌 菌种改造 生物过程优化 发酵放大技术 |
Industrial antibiotic-producing actinobacteria: from strain improvement to bioprocess optimization and scale-up |
| |
| YU Lan,GUO Mei-Jin,CHU Ju,ZHUANG Ying-Ping and ZHANG Si-Liang.Industrial antibiotic-producing actinobacteria: from strain improvement to bioprocess optimization and scale-up[J].Microbiology,2013,40(10):1810-1821. |
| |
| Authors: | YU Lan GUO Mei-Jin CHU Ju ZHUANG Ying-Ping and ZHANG Si-Liang |
| |
| Institution: | 1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China 2. School of Life Sciences, Huzhou Teachers College, Huzhou, Zhejiang 313000, China;1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China;1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China;1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China;1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China |
| |
| Abstract: | Actinobacteria are well known as they can produce a series of secondary metabolites with complex structures and various bioactivities. The industrial production of these secondary metabolites plays a vital role in medical and agricultural fields. Recent advances in strain improvement, bioprocess optimization and control, and fermentation scale-up were reviewed here. The holistic viewpoints and approaches applied in industrialized production of secondary metabolites by actinobacteria were discussed as well as the perspectives. |
| |
| Keywords: | Actinobacteria Strain improvement Bioprocess optimization Fermentation scale-up |
|
| 点击此处可从《微生物学通报》浏览原始摘要信息 |
| 点击此处可从《微生物学通报》下载免费的PDF全文 |
|
