Adenosine 3', 5'-monophosphate-dependent protein kinase in adipose tissue: inhibition by tolbutamide

Incubation of rat epididymal fat pads with 4 mM sodium tolbutamide for two hours produced half-maximal inhibition of adenosine 3′, 5′-monophosphate-dependent protein kinase. Related compounds (sodium paratoluenesulfonate, butylurea and sodium sulfadiazine) had minimal effects at similar concentrations. The antilipolytic effect of tolbutamide may be explained by its inhibition of protein kinase.