Secretome profiling of differentiated neural mes-c-myc A1 cell line endowed with stem cell properties |
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| Authors: | Valeria Severino Annarita Farina Luca Colucci-D'Amato Mafalda Giovanna Reccia Floriana Volpicelli Augusto Parente Angela Chambery |
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| Institution: | 1. Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, I-81100 Caserta, Italy;2. Biomedical Proteomics Research Group, Department of Bioinformatics and Structural Biology, Geneva University, CH-1211 Geneva, Switzerland;3. Department of Experimental Pharmacology, University of Naples “Federico II”, I-80131 Napoli, Italy;4. CNR, Institute of Genetics and Biophysics “Adriano Buzzati Traverso”, I-80131 Napoli, Italy |
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| Abstract: | Neural stem cell proliferation and differentiation play a crucial role in the formation and wiring of neuronal connections forming neuronal circuits. During neural tissues development, a large diversity of neuronal phenotypes is produced from neural precursor cells. In recent years, the cellular and molecular mechanisms by which specific types of neurons are generated have been explored with the aim to elucidate the complex events leading to the generation of different phenotypes via distinctive developmental programs that control self-renewal, differentiation, and plasticity. The extracellular environment is thought to provide instructive influences that actively induce the production of specific neuronal phenotypes. |
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| Keywords: | Secretome Stem cell Neuron Differentiation Mass spectrometry LC&ndash MS |
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