The surprising negative correlation of gene length and optimal codon use - disentangling translational selection from GC-biased gene conversion in yeast |
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| Authors: | Nina Stoletzki |
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| Affiliation: | (1) Ludwig-Maximilan Universit?t, Biocenter, Grosshadernerstr. 2, D-82152 Planegg-Martinsried, Hamburg, Germany;(2) Centre for the Study of Evolution, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK;(3) Current Address: Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, 77, Louis Pasteur Avenue, NRB, Boston, MA, USA |
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| Abstract: | Background Surprisingly, in several multi-cellular eukaryotes optimal codon use correlates negatively with gene length. This contrasts with the expectation under selection for translational accuracy. While suggested explanations focus on variation in strength and efficiency of translational selection, it has rarely been noticed that the negative correlation is reported only in organisms whose optimal codons are biased towards codons that end with G or C (-GC). This raises the question whether forces that affect base composition - such as GC-biased gene conversion - contribute to the negative correlation between optimal codon use and gene length. |
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