Surface display of Salmonella epitopes in <Emphasis Type="Italic">Escherichia coli</Emphasis> and <Emphasis Type="Italic">Staphylococcus carnosus</Emphasis> |
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| Authors: | Nguyen?Thanh?Nhan Ernesto?Gonzalez?de Valdivia Martin?Gustavsson Truong?Nam?Hai Email author" target="_blank">Gen?LarssonEmail author |
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| Institution: | (1) Division of Bioprocess Technology, School of Biotechnology, Royal Institute of Technology (KTH), SE-106 91 Stockholm, Sweden;(2) Vietnam Institute of Biotechnology (IBT), Vietnamese Academy of Science and Technology (VAST), Hanoi, Vietnam |
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| Abstract: | Background
Salmonella enterica serotype Enteritidis (SE) is considered to be one of the most potent pathogenic Salmonella serotypes causing food-borne disease in humans. Since a live bacterial vaccine based on surface display of antigens has many
advantages over traditional vaccines, we have studied the surface display of the SE antigenic proteins, H:gm and SefA in Escherichia coli by the β-autotransporter system, AIDA. This procedure was compared to protein translocation in Staphylococcus carnosus, using a staphylococci hybrid vector earlier developed for surface display of other vaccine epitopes. |
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