Recent Advancement of Chitosan-Based Nanoparticles for Oral Controlled Delivery of Insulin and Other Therapeutic Agents |
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Authors: | Anumita Chaudhury Surajit Das |
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Institution: | (1) Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Republic of Singapore;(2) Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Jurong Island, Singapore, 627833, Republic of Singapore |
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Abstract: | Nanoparticles composed of naturally occurring biodegradable polymers have emerged as potential carriers of various therapeutic
agents for controlled drug delivery through the oral route. Chitosan, a cationic polysaccharide, is one of such biodegradable
polymers, which has been extensively exploited for the preparation of nanoparticles for oral controlled delivery of several
therapeutic agents. In recent years, the area of focus has shifted from chitosan to chitosan derivatized polymers for the
preparation of oral nanoparticles due to its vastly improved properties, such as better drug retention capability, improved
permeation, enhanced mucoadhesion and sustained release of therapeutic agents. Chitosan derivatized polymers are primarily
the quaternized chitosan derivatives, chitosan cyclodextrin complexes, thiolated chitosan, pegylated chitosan and chitosan
combined with other peptides. The current review focuses on the recent advancements in the field of oral controlled release
via chitosan nanoparticles and discusses about its in vitro and in vivo implications. |
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Keywords: | |
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