The immune response of viral hepatitis patients who use narcotic preparations |
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| Authors: | Starostina I S Bogach V V Trotsenko O E Mikhaĭlov V I Tomilka G S Balakhontseva L A Durneva V M Kotov V O Fomenko V V Sokolovskiĭ L M |
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| Affiliation: | Research Institute of Epidemiology and Microbiology, Territorial Mental Health Center, Khabarovsk, Russia. |
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| Abstract: | The characteristics of cell-mediated and humoral immunity were studied in 611 patients with different etiological forms of acute virus hepatitides (HB, HC, HB + C, HC + HBsAg). As the result of the systematic abuse of psychoactive preparations, introduced by intravenous injection, in 166 patients (27.2%) drug addiction developed, ehile 445 (72.8%) patients had no addiction. The study revealed that in drug users with HB the secondary T-cell immunodeficiency of the hyposuppressor type in combination with depression in B-cell-mediated immunity (a decrease in the absolute number of B lymphocytes) could be registered, and in patients having no drug addiction the secondary T-cell immunodeficiency characterized by a decrease in the content of T helpers simultaneously with the increased content of T suppressors and B lymphocytes. |
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