MC3T3-E1 cell differentiation and in vivo bone formation induced by phosphoserine |
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| Authors: | Park Jin-Woo Kim Youn-Jeong Jang Je-Hee An Chang-Hyeon |
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| Institution: | (1) Department of Periodontology, School of Dentistry, Kyungpook National University, Daegu, 700-412, Republic of Korea;(2) Department of Oral and Maxillofacial Radiology, School of Dentistry, Kyungpook National University, Daegu, 700-412, Republic of Korea |
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| Abstract: | Bone formation induced by phosphoserine was investigated in vitro and in vivo using MC3T3-E1 cells and a rabbit calvarial
osseous defect model. MC3T3-E1 cells supplemented by phosphoserine displayed two-fold higher alkaline phosphatase activity
and mineralization nodule formation, and calvarial defects treated with phosphoserine showed statistically significant new
bone formation compared with the control (P < 0.05). |
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