Microarray for diagnostics of human pathogenic influenza-a virus subtypes |
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| Authors: | E V Kostina V A Ryabinin A P Agafonov V A Ternovoi A N Sinyakov |
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| Institution: | 1.Institute of Chemical Biology and Fundamental Medicine,Siberian Branch of Russian Academy of Sciences,Novosibirsk,Russia;2.Department of Molecular Virology,State Research Center of Virology and Biotechnology VECTOR,Koltsovo, Novosibirsk region,Russia |
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| Abstract: | An oligonucleotide microarray was developed for diagnostics of human pathogenic influenza-A virus subtypes. It contained discriminating
probes for H1, H2, H3, H5, H7, and H9 subtypes of hemagglutinin and for N1, N2, and N7 subtypes of neuraminidase. An additional
set of probes was used for revealing the M-gene of the influenza-A virus. The proposed microarray was tested on samples of
pathogenic H5N1 avian influenza virus, pandemic H1N1 swine influenza virus, and seasonal H1N1 and H3N2 influenza viruses.
The microarray can be used for the analysis both of cultivated strains and clinical specimens. |
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